05 Oct '11, 11am

Genes change message after newborn rats given BPA. — Environmental Health News

Genes change message after newborn rats given BPA. — Environmental Health News

What did they do? The researchers injected newborn male rat pups with 2.4 micrograms of BPA in sesame oil per day for the first five days after birth. Experimental control pups received only the oil injection during this period. This BPA dose was chosen because it is the lowest dose previously found to impair male fertility. Further, this dose is relevant to human exposures. It is within the range of documented children's and adult occupational exposures. After treatment, pups were raised to adults. Genetic material – DNA and RNA – and proteins in the testes tissues were analyzed. The researchers measured the degree of epigenetic modification of the DNA, the amount of RNA coding that produce the estrogen receptors and the amount of proteins in the testes that are responsible for methylating DNA. Estrogen hormones play an important role in male reproduction. The molecular s...

Full article: http://www.environmentalhealthnews.org/ehs/newscience/201...

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